SysMO is a European trans-national funding and research initiative on "Systems Biology of Microorganisms".
The goal pursued by SysMO is to record and describe the dynamic molecular processes occurring in microorganisms
and to present these processes in the form of computerized mathematical models.
The aim is to pool research capacities and know-how from the SysMO projects.
Each of the individual projects in SysMO are working towards different research outcomes and represent a cross-section
of microorganisms, including bacteria, archaea and yeast. The environmental conditions for each organism vary widely
with organisms growing in culture, soil, water and animal hosts.
As a consequence of this diversity, there is no one model for experimentation or for the types of data collected
and the types of models produced. In order to pool the research outcomes for SysMO, our job in SysMO-DB is to support
and manage this diversity and promote a shared understanding across the community by using the same technologies.
SysMO-DB is supporting the 13 different research projects in the SysMO consortium. These are:
- BaCell-SysMO - The transition from growing to non-growing Bacillus subtilis cells - A systems biology approach.
- COSMIC - Systems Biology of Clostridium acetobutylicum - a possible answer to dwindling crude oil reserves.
- SUMO - Systems Understanding of Microbial Oxygen Responses.
- KOSMOBAC - Ion and solute homeostasis in enteric bacteria: an integrated view from the interface of modelling and experimentation.
- SysMO-LAB - Comparative Systems Biology: Lactic Acid Bacteria.
- PSYSMO - Systems analysis of biotech induced stresses: towards a quantum increase in process performance in the cell factory Pseudomonas putida.
- SCaRAB - Systems Biology of a genetically engineered Pseudomonas fluorescens with inducible exo-polysaccharide production: analysis of the dynamics and robustness of metabolic networks.
- MOSES - MicroOrganism Systems Biology: Energy and Saccharomyces cerevisiae.
- TRANSLUCENT - Gene interaction networks and models of cation homeostasis in Saccharomyces cerevisiae.
- STREAM - Global metabolic switching in Streptomyces coelicolor.
- SulfoSYS - Silicon cell model for the central carbohydrate metabolism of the archaeon Sulfolobus solfataricus under temperature variation.
- SilicoTryp - The creation of a “Silicon Trypanosome”, a comprehensive, experiment-based, multi-scale mathematical model of trypanosome physiology.
- Noisy Strep - Unravelling how transcription fidelity and processivity influences (noisy) gene expression in the human pathogen Streptococcus pneumoniae.